Toronto Blue Jays (Drew Hutchison) @New York Yankees (Masahiro Tanaka)
WTWF: Alex Rodriguez makes his regular season debut after being suspended for all of last season. He'll turn 40 in July and hit .244/.348/.423 in 2013, yet people are still drafting him in fantasy baseball. Go figure.
My Pick: Yankees 5, Blue Jays 2
Minnesota Twins (Phil Hughes) @Detroit Tigers (David Price)
WTWF: Phil Hughes started 32 games last year and walked just 16 batters. Only twice did he walk more than one batter in a game and the most he walked in a game was three.
My Pick: Tigers 8, Twins 4
Colorado Rockies (Kyle Kendrick) @Milwaukee Brewers (Kyle Lohse)
WTWF: Can Troy Tulowtizki and Carlos Gonzalez make it through this game without being injured?
My Pick: Brewers 7, Rockies 5
Boston Red Sox (Clay Buchholz) @Philadelphia Phillies (Cole Hamels)
WTWF: Many people thought Cole Hamels would have been traded by now, but he remains a Phillie. The Red Sox could use an upgrade in their rotation and have many good prospects. A trade would make sense for both sides, if not now, then surely before July is up.
My Pick: Red Sox 6, Phillies 3
Baltimore Orioles (Chris Tillman) @Tampa Bay Rays (Chris Archer)
WTWF: Can the Rays lure more than 30,000 fans to their Opening Day game in their terrible ballpark?
My Pick: Rays 4, Orioles 3
New York Mets (Bartolo Colon) @Washington Nationals (Max Scherzer)
WTWF: The 210-million-dollar-man, Max Scherzer, makes his Washington Nationals debut.
My Pick: Nationals 6, Mets 2
Chicago White Sox (Jeff Samardzija) @Kansas City Royals (Yordano Ventura)
WTWF: Jeff Samardizja is a free agent at the end of the year and is looking to up his value with a good season with the Sox.
My Pick: Royals 5, White Sox 4
Los Angeles Angels (Jered Weaver) @Seattle Mariners (Felix Hernandez)
WTWF: King Felix has started the last six Opening Day games for the Mariners and seven of the last eight, with Erik Bedard sneaking in there for the 2008 opener. The Mariners have won eight straight openers.
My Pick: Mariners 5, Angels 2
Pittsburgh Pirates (Francisco Liriano) @Cincinnati Reds (Johnny Cueto)
WTWF: Cincy outfielder Jay Bruce hit .217/.281/.373 last year and was particularly bad against left-handed-pitchers: .161/.217/.339. Francisco Liriano is a left-handed pitcher.
My Pick: Pirates 4, Reds 3
San Diego Padres (James Shields) @Los Angeles Dodgers (Clayton Kershaw)
WTWF: The new-look Padres start the season facing the world's greatest pitcher, Clayton Kershaw. Over/under on hits by the Padres' three new outfielders: 1.5.
My Pick: Dodgers 5, Padres 0
Atlanta Braves (Julio Teheran) @Miami Marlins (Henderson Alvarez)
WTWF: Two teams on opposite paths. The Braves are in full-on rebuilding mode while the Marlins want to be playoff contenders right here, right now.
My Pick: Marlins 5, Braves 3
Cleveland Indians (Corey Kluber) @Houston Astros (Dallas Keuchel)
WTWF: The 2014 AL Cy Young award winner Corey Kluber squares off against the 2014 AL Batting Champion, Jose Altuve. Also, Dallas Keuchel will pitch for the Astros.
My Pick: Indians 7, Astros 3
San Francisco Giants (Madison Bumgarner) @Arizona Diamondbacks (Josh Collmenter)
WTWF: The defending World Champion San Francisco Giants take on the worst team in their division and Madison Bumgarner is on the hill. I believe this is the biggest mismatch of the day.
My Pick: Madison Bumgarners 5, Diamondbacks 2
Texas Rangers (Yovani Gallardo) @Oakland Athletics (Sonny Gray)
WTWF: The depth chart for the Oakland Athletics is shown below (from ESPN.com) and has Craig Gentry playing both left field and center field. It's a bold strategy, Cotton.
My Pick: Athletics 5, Rangers 4